Dermal templates to prevent and treat wound biofilms
Official title: Novel dermal templates for prevention and treatment of biofilms in cutaneous wounds
Funded at Gel4med, INC. · NIH-11357707 · Data updated 2026-11-12
A patient-friendly approach is being developed to prevent and eradicate biofilms in acute and chronic wounds using a peptide-based, tissue-friendly membrane called G4B.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Gel4med, INC. NIH-funded |
| Lab location | 1 site (Brighton, United States) |
| Project start | April 1, 2019 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,000,000 |
| NIH project number | 5R44AI143079-03 |
| Project ID | NIH-11357707 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with acute or chronic skin wounds at risk for or currently dealing with biofilm-related infections, including diabetic foot ulcers.
✕Less likely to help
Patients without wounds or those not at risk for wound biofilms may not benefit.
What this research studies
This project aims to improve wound healing by using a G4B peptide membrane that fits closely to the wound bed to prevent dead spaces where bacteria grow. It targets infections in diabetic foot ulcers and other wounds that commonly harbor biofilms, which delay healing. The work builds on early data showing antimicrobial activity and scaffolding properties to support faster, infection-free healing.
Why it matters
Potential benefit: If successful, it could reduce infections and improve healing times for difficult wounds.
How similar studies have gone: Previous data suggest anti-biofilm membranes can reduce bacteria and support healing, but this specific G4B approach is being tested.
Where this research is happening
-
Gel4med, INC.
Brighton, United States Active
Researchers
- Principal investigator: Mehta, Manav — Gel4med, INC.
- Study coordinator: Mehta, Manav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.