Dementia, APOE genes, and blood tests in Native American communities
Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communities
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11322631
This project looks at how APOE genes and simple blood tests relate to dementia in Native American communities.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11322631 on ClinicalTrials.gov |
What this research studies
Researchers will partner with Native American Tribal Nations to collect health information, cognitive histories, and blood samples. They will measure blood-based Alzheimer’s disease biomarkers and APOE genetic types to see which forms of dementia are present. The team will compare biomarker results and APOE effects in Native American participants to what is known from other groups. Findings will help determine whether existing blood tests and genetic risk markers work the same way in Native American communities.
Who could benefit from this research
Good fit: Ideal participants are Native American adults—especially older adults—with or without memory concerns who can provide health history and a blood sample.
Not a fit: People who are not Native American or who cannot provide blood samples or health information are unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to more accurate blood tests, better risk information, and fairer access to future dementia treatments for Native American people.
How similar studies have performed: Blood-based AD biomarkers and APOE risk have shown promise in other populations but have been little tested in Native American communities.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANTYH, WILLIAM G — UNIVERSITY OF MINNESOTA
- Study coordinator: MANTYH, WILLIAM G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.