Delivering small RNAs to treat cancer and COVID-19
Ligand-mediated, vehicle-free delivery of small RNAs
This study is exploring a new way to deliver tiny RNA molecules to cancer cells and possibly to cells affected by COVID-19, aiming to improve treatment for patients with cancers like breast and colon cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10925265 on NIH RePORTER |
What this research studies
This research investigates a novel method for delivering small RNA molecules, specifically microRNAs, to cancer cells and potentially to cells affected by COVID-19. The approach focuses on using a vehicle-free method that enhances the stability and effectiveness of these RNA therapeutics, particularly targeting tumors that overexpress the folate receptor. By improving the delivery system, the research aims to achieve better treatment outcomes for patients with various cancers, including breast and colon cancer, as well as addressing challenges posed by the COVID-19 virus.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include patients with breast cancer, colon cancer, or those affected by COVID-19.
Not a fit: Patients with conditions unrelated to cancer or COVID-19 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments and improved therapeutic options for patients affected by COVID-19.
How similar studies have performed: Other research has shown success with RNA therapeutics, particularly in the context of mRNA vaccines and RNAi drugs, indicating a promising avenue for further exploration.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Kasinski, Andrea L — Purdue University
- Study coordinator: Kasinski, Andrea L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.