Delivering immune-modulating proteins to the brain non-invasively
Official title: Non-invasive and Long-lived CNS Delivery of Treg-inducing Cytokine Depots
Funded at University of Michigan at Ann Arbor · NIH-11022493 · Data updated 2026-11-12
This study is looking at a new way to deliver a special protein to the brain that could help reduce inflammation and protect against conditions like Alzheimer's and brain injuries, offering patients a non-invasive treatment option to improve their brain health and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $545,630 |
| NIH project number | 1R01EB036493-01 |
| Project ID | NIH-11022493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neuroinflammatory conditions such as Alzheimer's disease, traumatic brain injury, or multiple sclerosis.
✕Less likely to help
Patients with non-neuroinflammatory conditions or those who do not have access to the research location may not benefit from this research.
What this research studies
This research focuses on developing a method to deliver a specific immune-modulating protein, IL-2, directly to the brain to help regulate inflammation. By using bispecific antibodies that can cross the blood-brain barrier, the study aims to create long-lasting cytokine depots in the central nervous system (CNS). This approach could potentially prevent or reduce damage from various neurological conditions, including Alzheimer's disease and traumatic brain injury. Patients may benefit from a non-invasive treatment that could improve their neurological health and quality of life.
Why it matters
Potential benefit: If successful, this research could provide a new, non-invasive treatment option for patients with neuroinflammatory conditions, potentially improving their symptoms and overall health.
How similar studies have gone: While the approach of using bispecific antibodies for CNS delivery is innovative, similar strategies have shown promise in other contexts, indicating potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Tessier, Peter M — University of Michigan at Ann Arbor
- Study coordinator: Tessier, Peter M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.