Deep genetic and immune profiling for high‑risk multiple myeloma
Project 2: Multi-Omics of high-risk MM
['FUNDING_OTHER'] · MAYO CLINIC ARIZONA · NIH-11176758
This project uses detailed genetic, immune, and environmental testing to help people with high‑risk multiple myeloma who don't respond well to treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ARIZONA (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-11176758 on ClinicalTrials.gov |
What this research studies
You would be followed over time while doctors collect blood, bone marrow, and other samples to look at genes, immune cells, and environmental exposures. The team will apply state‑of‑the‑art sequencing and other 'omics' tests to build a detailed picture of what drives disease in patients with 'double‑hit' high‑risk MM. This is a Phase 2 clinical trial that compares these deeply studied patients with a large clinical control database to find patterns linked to treatment failure. The study will create a comprehensive, longitudinal data resource designed to guide future personalized therapies.
Who could benefit from this research
Good fit: Ideal candidates are adults with high‑risk 'double‑hit' multiple myeloma who are starting or not responding to standard therapies and can provide blood and bone marrow samples.
Not a fit: Patients with low‑risk multiple myeloma or conditions unrelated to multiple myeloma are unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could reveal biological pathways behind treatment resistance and point to new targeted therapies for high‑risk MM patients.
How similar studies have performed: Previous deep genomic and immune profiling studies in small patient groups have yielded useful clues, but this comprehensive, longitudinal multi‑omics approach in high‑risk MM is relatively new.
Where this research is happening
SCOTTSDALE, UNITED STATES
- MAYO CLINIC ARIZONA — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRAGGIO, ESTEBAN — MAYO CLINIC ARIZONA
- Study coordinator: BRAGGIO, ESTEBAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.