Data and bioinformatics support for aging T cells and immune rejuvenation
Data Sciences Core
This project helps scientists analyze cell and gene data to understand how T cells change with age and how that knowledge might improve immune health for older adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11308356 on NIH RePORTER |
What this research studies
This core provides statistical, bioinformatics, and computing support to researchers studying how T cells age and how they might be rejuvenated. It analyzes data from lab and mouse experiments and performs single-cell RNA sequencing processing to identify which cell types and genes change with age. The team builds reproducible analysis tools and shared data platforms so results from different projects can be combined and compared. By coordinating statistics and computing across the program, the core speeds up discovery about immune aging.
Who could benefit from this research
Good fit: People likely to benefit in the future include older adults concerned about weakened immunity or those interested in participating in eventual immune-rejuvenation trials.
Not a fit: Patients with health issues unrelated to immune aging are unlikely to receive direct benefit from this data-science core.
Why it matters
Potential benefit: If successful, this work could help identify ways to restore immune function in older adults and improve responses to infections and vaccines.
How similar studies have performed: Single-cell sequencing and advanced biostatistics have already revealed important immune-aging changes, though integrating these methods across a multi-project program is a relatively novel approach.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Lafleur, Bonnie — University of Arizona
- Study coordinator: Lafleur, Bonnie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.