Daple gene fusions in some blood cancers
Official title: Elucidating the molecular mechanism of Daple- FLT3 and Daple-PDGFRB gene fusion in blood cancers
Funded at California State Poly U Pomona · NIH-11141013 · Data updated 2026-11-12
Researchers are looking at how Daple fused with FLT3 or PDGFRB makes certain leukemias grow and resist treatment so new ways to target them can be found.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State Poly U Pomona NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $183,750 |
| NIH project number | 5R16GM146720-04 |
| Project ID | NIH-11141013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with leukemia whose tumor testing shows Daple-FLT3 or Daple-PDGFRB gene fusions would be the most relevant group.
✕Less likely to help
Patients whose cancers do not carry these specific gene fusions or whose disease is driven by unrelated mechanisms are unlikely to benefit directly from these findings.
What this research studies
This project uses lab-based molecular experiments to see how Daple-FLT3 and Daple-PDGFRB gene fusions change signaling in leukemia cells. Scientists will map which cell signaling pathways become overactive and test how those changes cause resistance to existing kinase-blocking drugs. The team will use cell models and molecular assays to identify points where multiple cancer-driving pathways converge. Results aim to reveal vulnerabilities that could be pursued with new drugs or combination strategies.
Why it matters
Potential benefit: If successful, this work could point to new drug targets or strategies that overcome resistance in leukemias driven by these gene fusions.
How similar studies have gone: Kinase fusions in blood cancers have been successfully treated with targeted kinase inhibitors, but Daple-related fusion mechanisms are less studied and this work is relatively novel.
Where this research is happening
-
California State Poly U Pomona
Pomona, United States Active
Researchers
- Principal investigator: Ear, Jason — California State Poly U Pomona
- Study coordinator: Ear, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.