CSF Proteogenomics to Improve Diagnosis and Management of Diffuse Gliomas
Official title: Integration of CSF Proteogenomics in the Diagnosis and Management of Diffuse Gliomas
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11413674 · Data updated 2026-11-12
A study from Penn State Hershey aims to use proteins found in CSF to better diagnose and guide treatment for adults with diffuse gliomas.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | July 3, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $624,845 |
| NIH project number | 5R01CA279357-03 |
| Project ID | NIH-11413674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) with diffuse gliomas who have undergone surgery and adjuvant therapy and are being monitored for recurrence.
✕Less likely to help
Patients without gliomas or those not undergoing CSF-based testing may not benefit from this approach.
What this research studies
This project will look at proteins in spinal fluid to help distinguish tumor recurrence from treatment effects in adults with gliomas. By combining CSF proteins with genomic and imaging information, clinicians may get a clearer, non-invasive picture of how the tumor is evolving. The approach focuses on how tumor biology in the CSF reflects disease status and response to therapy, with the goal of guiding personalized management. The research team plans to analyze small CSF samples and integrate proteomics with existing molecular data to identify useful biomarkers.
Why it matters
Potential benefit: If successful, patients could experience more accurate monitoring and tailored treatment decisions with less invasive testing.
How similar studies have gone: Preliminary work in CSF proteomics shows promise for tumor biomarkers, but this exact approach in diffuse gliomas is investigational.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Mansouri, Alireza — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Mansouri, Alireza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.