CSDE1 protein's role in helping the VSV virus copy itself
Characterizing the role of CSDE1 as a critical co-factor for VSV replication.
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11283937
This project looks at how changes in a human protein called CSDE1 let the VSV virus grow in cells, with the goal of improving virus-based cancer therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11283937 on ClinicalTrials.gov |
What this research studies
Researchers grew human and mouse cells under low, long-term exposure to VSV to see how some cells stop being killed by the virus. They used RNA sequencing to find hundreds of mutations and focused on a single change in the CSDE1 gene that appeared repeatedly in resistant cells. The team then forced the virus to evolve in those mutant cells and found viral changes that restored its ability to replicate, showing a co-evolution between cell and virus. Understanding these interactions may help scientists design oncolytic VSVs that are more effective and less likely to be blocked by patient cells.
Who could benefit from this research
Good fit: Patients with cancer who are candidates for or interested in future virus-based (oncolytic) therapies, or those willing to donate tumor samples for laboratory studies, would be most relevant to this work.
Not a fit: People with conditions unrelated to oncolytic viral therapy or those seeking immediate clinical treatment are unlikely to receive direct benefit from this laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could help make oncolytic VSV-based cancer treatments more reliable and safer by reducing or predicting viral resistance.
How similar studies have performed: Related laboratory studies have shown APOBEC-driven mutation and viral escape in cell models, but translating these findings into proven, safe patient treatments remains at an early stage.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILE, RICHARD G. — MAYO CLINIC ROCHESTER
- Study coordinator: VILE, RICHARD G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.