Creating zebrafish models to study human genetic diseases
Official title: Resource of zebrafish models of human diseases
Funded at University of Oregon · NIH-10795508 · Data updated 2026-11-12
This study is creating special zebrafish that can help us learn more about rare genetic diseases in people, so we can better understand these conditions and help those who are still looking for answers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $743,926 |
| NIH project number | 1R24OD036061-01 |
| Project ID | NIH-10795508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with undiagnosed rare genetic diseases who have undergone whole-exome or whole-genome sequencing.
✕Less likely to help
Patients with well-characterized genetic conditions or those not involved in genetic research may not benefit from this research.
What this research studies
This research focuses on developing zebrafish models that mimic human genetic diseases to better understand the underlying biology of these conditions. By collaborating with clinical sites, the project will gather genetic information from patients with undiagnosed rare diseases. Using advanced CRISPR technology, researchers will create specific genetic modifications in zebrafish to study the effects of these variants. The resulting models will be rigorously validated and made available to the scientific community for further research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for rare genetic diseases.
How similar studies have gone: Previous research using zebrafish models has shown success in elucidating the functions of genes related to various diseases, indicating a promising approach.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Westerfield, Monte — University of Oregon
- Study coordinator: Westerfield, Monte
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.