Creating vascularized tumor models for testing cancer drugs
Vascularized tumor explants for drug testing
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10877712
This study is working on a new way to grow tumor samples in the lab that look and act like real human tumors, which will help doctors test how well different cancer treatments work for patients with pancreatic cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10877712 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a method to create vascularized tumor explants that mimic the biology of human tumors. By integrating tumor samples with engineered blood vessels and supportive tissue in a lab setting, the researchers aim to create a platform that allows for personalized drug testing. This approach will enable high-throughput assays to evaluate how specific tumors respond to various cancer treatments, particularly for patients with pancreatic ductal adenocarcinoma. The goal is to improve the understanding of tumor biology and enhance the effectiveness of chemotherapy tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing treatment.
Not a fit: Patients with cancers other than pancreatic ductal adenocarcinoma may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized cancer treatments based on individual tumor responses.
How similar studies have performed: Other research has shown promise in using similar tumor explant models for drug testing, indicating a potential for success in this approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUNN, LANCE L. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MUNN, LANCE L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.