Creating vaccines to fight a virus linked to certain cancers
Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study
['FUNDING_U01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11002590
This study is testing new vaccines to help protect against a virus linked to serious health issues like Kaposi's sarcoma, using mice to see how well these vaccines work.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11002590 on ClinicalTrials.gov |
What this research studies
This research focuses on developing three innovative vaccine platforms aimed at combating Kaposi's sarcoma-associated herpesvirus (KSHV), which is linked to serious conditions like Kaposi's sarcoma and primary effusion lymphomas. The researchers will utilize a mouse model to test these vaccines, employing a modified version of another virus, Murine Herpesvirus 68, to simulate KSHV infection. By doing so, they hope to evaluate the effectiveness of these vaccines in preventing KSHV-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for KSHV-related diseases, including those with compromised immune systems or those living in endemic regions.
Not a fit: Patients who are not at risk for KSHV infection or those who do not have related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that prevent KSHV infection and its associated cancers, significantly improving patient outcomes.
How similar studies have performed: While vaccine development for KSHV is relatively novel, similar approaches using animal models have shown promise in other viral vaccine research.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JUNG, JAE U — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: JUNG, JAE U
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus