Creating vaccines for diseases caused by flaviviruses
Development of a vaccination platform for emerging flavivirus infections
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10973611
This study is working on a new type of vaccine to help protect people from flavivirus infections like dengue, Zika, and West Nile virus, using special techniques to make sure the vaccines are safe and can boost your immune system without making you sick.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10973611 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new vaccination platform to combat flavivirus infections, which include diseases like dengue, Zika, and West Nile virus. The approach utilizes RNA structural data to create attenuated vaccines that are designed to be safe and effective. By modifying specific regions of the virus's genetic material, researchers aim to produce vaccines that can stimulate a strong immune response without causing disease. The project will involve pre-clinical testing in animal models to evaluate the safety and effectiveness of these candidate vaccines.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be adults over the age of 21 who are at risk of flavivirus infections.
Not a fit: Patients who are not at risk for flavivirus infections or those who are under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that protect against several serious viral infections transmitted by mosquitoes and ticks.
How similar studies have performed: Other research has shown promise in developing vaccines using similar attenuation approaches for viral infections, indicating potential for success in this area.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BECKHAM, JOHN DAVID — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BECKHAM, JOHN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.