Creating tools to understand how cells communicate with each other using advanced data techniques
Official title: Development of tools for analyzing cell-cell communication using spatial transcriptomic data
Funded at University of California-Irvine · NIH-10774801 · Data updated 2026-11-12
This study is exploring new ways to understand how cells talk to each other, which is really important for how our bodies work, by using advanced technology to look closely at their interactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 20, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $356,462 |
| NIH project number | 1R01GM152494-01 |
| Project ID | NIH-10774801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve complex cellular interactions, such as cancer or autoimmune diseases.
✕Less likely to help
Patients with conditions unrelated to cellular communication or those who do not have access to the required spatial transcriptomic technologies may not benefit from this research.
What this research studies
This research focuses on developing new mathematical and computational methods to analyze how cells communicate with each other through ligand-receptor interactions. By utilizing advanced spatial transcriptomic data, the project aims to enhance our understanding of cell-cell communication, which is crucial for the functioning of biological tissues. The researchers will address challenges in inferring these communication links, leveraging single-cell genomics to improve the accuracy of their analyses. This innovative approach could lead to significant biological discoveries and insights into cellular interactions.
Why it matters
Potential benefit: If successful, this research could provide deeper insights into cellular communication, potentially leading to new therapeutic strategies for various diseases.
How similar studies have gone: Other research has shown success in using single-cell genomics for understanding cellular interactions, but the application of spatial transcriptomics for this purpose is relatively novel.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Nie, Qing — University of California-Irvine
- Study coordinator: Nie, Qing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.