Creating tools to understand how biological molecules interact
Official title: Development of Computational Tools and Their Applications to Various Biological Systems
Funded at Lehigh University · NIH-10842739 · Data updated 2026-11-12
This study is creating new computer tools to help scientists better understand how proteins and other important molecules in our bodies interact, which can lead to better drug development and insights into diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $393,066 |
| NIH project number | 1R35GM153458-01 |
| Project ID | NIH-10842739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to protein-ligand interactions, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions that do not involve molecular interactions or those who are not engaged in biomedical research may not receive direct benefits from this research.
What this research studies
This research focuses on developing advanced computational tools to analyze and simulate the interactions of biological macromolecules, which are essential for cellular functions. By enhancing platforms like CHARMM-GUI and G-LoSA, the project aims to improve our understanding of protein-ligand and protein-protein interactions at a molecular level. These tools will help researchers model complex biological systems and predict how different molecules bind together, which is crucial for drug development and understanding disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug designs and therapies by providing deeper insights into molecular interactions.
How similar studies have gone: Previous research has shown success in using computational tools for molecular modeling and interaction studies, indicating that this approach is both promising and established.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Im, Wonpil — Lehigh University
- Study coordinator: Im, Wonpil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.