Creating tools to target specific brain cell types using viruses.
Enhancer AAV toolbox for cell classes and subclasses in the brains of mouse, macaque and marmoset.
['FUNDING_U01'] · ALLEN INSTITUTE · NIH-11118024
This study is all about creating special tools to help scientists target and understand different types of brain cells in mice and monkeys, which could lead to better treatments for brain-related conditions.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALLEN INSTITUTE (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11118024 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a variety of recombinant adeno-associated virus (AAV) tools designed to target specific classes and subclasses of brain cells in mice, marmosets, and macaques. By utilizing advanced techniques such as single-nucleus multiome datasets and various imaging and transcriptomic methods, the researchers aim to identify and characterize enhancers that can effectively drive gene expression in these targeted cells. The project will involve extensive screening and testing of these tools to ensure their effectiveness and specificity in different brain regions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with brain disorders that affect specific cell types, particularly those related to basal ganglia diseases.
Not a fit: Patients with generalized brain conditions not linked to specific cell types or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise methods for studying and potentially treating brain disorders by targeting specific cell types.
How similar studies have performed: Other research has shown promise in using AAV tools for targeted gene delivery in the brain, indicating that this approach has potential for success.
Where this research is happening
SEATTLE, UNITED STATES
- ALLEN INSTITUTE — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TASIC, BOSILJKA — ALLEN INSTITUTE
- Study coordinator: TASIC, BOSILJKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Basal Ganglia Diseases, Basal Ganglia Disorders