Creating tools to study how proteins interact with DNA
Official title: Development of biological structural tools for the study of protein-DNA complexes
Funded at Florida International University · NIH-11080253 · Data updated 2026-11-12
This study is exploring how proteins and DNA work together in our bodies, which is important for things like controlling genes and fixing DNA, and it aims to create new tools to better understand these interactions, potentially helping us learn more about diseases linked to them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | May 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $327,270 |
| NIH project number | 5R35GM153450-02 |
| Project ID | NIH-11080253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that involve DNA repair mechanisms or protein-DNA interactions.
✕Less likely to help
Patients with conditions unrelated to DNA or protein interactions may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between proteins and DNA, which are crucial for many biological processes such as gene regulation and DNA repair. The project aims to develop advanced mass spectrometry techniques and structural tools to analyze these interactions in their natural environments. By using innovative methods to separate and characterize biomolecular complexes, the research seeks to provide deeper insights into the molecular mechanisms that govern protein-DNA interactions. This could lead to a better understanding of diseases related to these processes.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and potentially lead to new therapeutic strategies for diseases linked to DNA and protein interactions.
How similar studies have gone: Previous research has shown success in using advanced mass spectrometry techniques to study biomolecular interactions, indicating that this approach has potential for significant findings.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Fernandez-Lima, Francisco — Florida International University
- Study coordinator: Fernandez-Lima, Francisco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.