Creating tools to study how dissolved gases affect tissue function
Official title: Development of Analytical Tools for Concentration and Real-Time Control of Dissolved Gases and Their Regulation of Tissue Function
Funded at University of Washington · NIH-11013831 · Data updated 2026-11-12
This study is working on new ways to measure and control important gases in your blood, like oxygen and carbon dioxide, to help us better understand how they affect your health and improve treatments for conditions like diabetes, heart disease, and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $437,715 |
| NIH project number | 5R01GM148741-03 |
| Project ID | NIH-11013831 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with conditions affected by tissue function and gas signaling, such as diabetes, cardiovascular diseases, and certain cancers.
✕Less likely to help
Patients with conditions unrelated to tissue gas signaling or those who do not require interventions involving gas regulation may not benefit from this research.
What this research studies
This research focuses on developing analytical tools to measure and control dissolved gases in biological samples, such as blood. These gases, including oxygen, carbon dioxide, and trace signaling gases like nitric oxide, play crucial roles in various bodily functions, including heart rate regulation and immune responses. By accurately measuring these gases in real-time, the research aims to enhance our understanding of their effects on tissue function and potentially improve treatments for conditions like diabetes, atherosclerosis, and cancer. The approach involves innovative methodologies that go beyond traditional chemical donors of gases, which may not provide precise control over gas levels.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for a range of serious health conditions by enabling better understanding and manipulation of gas signaling in tissues.
How similar studies have gone: Other research has shown promise in utilizing gas signaling for therapeutic purposes, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Sweet, Ian R — University of Washington
- Study coordinator: Sweet, Ian R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.