Creating tools to selectively edit proteins in the body
Official title: Towards the Design of Programmable, Isoform-Selective Proteome Editing System
Funded at Duke University · NIH-11131249 · Data updated 2026-11-12
This study is working on new ways to change proteins in the body using smart technology, which could help treat diseases like cancer and those related to aging by making sure the right proteins are targeted and managed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $402,500 |
| NIH project number | 5R35GM155282-02 |
| Project ID | NIH-11131249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to protein dysfunction, such as certain cancers or age-related diseases.
✕Less likely to help
Patients with conditions not related to protein dysfunction or those who do not respond to protein-targeted therapies may not benefit from this research.
What this research studies
This research aims to develop innovative tools for editing proteins in the body, which could help in treating various diseases. By using advanced artificial intelligence techniques, the researchers will design specific peptides that can modify proteins based on their sequences. This approach allows for precise targeting of both stable and unstable proteins, potentially leading to new treatments for conditions like cancer and age-related diseases. The project will also explore ways to stabilize or degrade proteins that contribute to disease, enhancing the effectiveness of these treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that precisely target and modify disease-related proteins, improving patient outcomes.
How similar studies have gone: Other research has shown promise in using CRISPR and similar technologies for genome editing, suggesting potential success for this novel approach in proteome editing.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Chatterjee, Pranam — Duke University
- Study coordinator: Chatterjee, Pranam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.