Creating tools to produce proteins that help understand cancer treatment
A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides
This study is working on a new tool to help scientists better detect and measure specific proteins that play important roles in cancer, which could lead to improved treatments and a deeper understanding of how cancer develops.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10909138 on NIH RePORTER |
What this research studies
This research focuses on developing a synthetic toolkit that enhances the production of tyrosine phosphorylated proteins, which are crucial for understanding cancer biology. By improving the detection and measurement of these proteins, the project aims to shed light on their roles in cancer progression and treatment responses. The researchers will refine this technology to ensure it is more reproducible and cost-effective, making it accessible for broader applications in cancer research. This work could lead to better therapeutic interventions by providing insights into the 'dark phosphoproteome' that is often overlooked in cancer studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer, particularly those whose treatment responses may be influenced by tyrosine phosphorylation.
Not a fit: Patients with non-cancerous conditions or those not affected by tyrosine phosphorylation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by providing better tools for understanding how proteins function in cancer progression.
How similar studies have performed: Previous research has shown promise in similar approaches to studying tyrosine phosphorylation, indicating potential for success in this novel application.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Naegle, Kristen M — University of Virginia
- Study coordinator: Naegle, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.