Creating tools to observe brain signaling in mice during learning and memory.
Development of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving mice
This study is exploring new tools to watch how different brain signals work together in mice while they learn and remember things, which could help us understand more about brain changes related to conditions like autism and schizophrenia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10505852 on NIH RePORTER |
What this research studies
This research focuses on developing innovative biosensors that can monitor multiple signaling pathways in the brain of behaving mice. By using advanced imaging techniques, the researchers aim to visualize how these pathways interact during critical processes like learning and memory. This approach will help uncover the underlying mechanisms of neuronal plasticity, which is essential for understanding various neurological disorders. The study seeks to provide insights into how disruptions in these pathways can lead to conditions such as autism and schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with neurological disorders such as autism, schizophrenia, or intellectual disabilities.
Not a fit: Patients with purely physical health issues unrelated to neurological or psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurological and psychiatric disorders.
How similar studies have performed: Other research has shown promise in using biosensors for monitoring cellular activities, indicating potential success for this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Huganir, Richard L — Johns Hopkins University
- Study coordinator: Huganir, Richard L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.