Creating tools to find RNA interactions with DNA structures
Developing a genomic toolkit to identify RNAs within non-canonical DNA structures
This study is exploring new ways to find out how certain long non-coding RNAs interact with DNA, which could help us understand how these molecules affect important processes in our cells, and this knowledge might lead to better treatments for diseases related to gene regulation.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10708851 on NIH RePORTER |
What this research studies
This research focuses on developing innovative technologies to identify specific regions within long non-coding RNAs (lncRNAs) that interact with DNA through unique structures called R-loops and RNA-triplexes. These lncRNAs play a crucial role in regulating important cellular processes such as gene transcription and DNA repair. By mapping these interactions at a high resolution, the research aims to enhance our understanding of how lncRNAs influence gene regulation and chromatin dynamics. Patients may benefit from insights gained into the molecular mechanisms of various diseases linked to gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or diseases linked to dysregulated gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by long non-coding RNAs may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating diseases related to gene regulation.
How similar studies have performed: While the specific approach of mapping RNA-DNA interactions through R-loops and triplexes is relatively novel, similar genomic technologies have shown promise in other areas of gene regulation research.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sarma, Kavitha — Wistar Institute
- Study coordinator: Sarma, Kavitha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.