Creating tools to control gene activity through epigenetic changes
"Developing A Comprehensive Toolkit for Chemical Inducible Epigenome Remodeling"
This study is exploring new ways to change how genes work in our bodies, which could help us understand diseases better and lead to improved treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11072961 on NIH RePORTER |
What this research studies
This research focuses on developing innovative tools that can manipulate various epigenetic mechanisms, such as DNA methylation and chromatin remodeling, which play a crucial role in regulating gene expression. By using advanced techniques like CRISPR and chemically induced proximity, the project aims to create methods that allow for precise control of these processes in a targeted manner. This could help researchers better understand how different epigenetic pathways interact and contribute to diseases. Patients may benefit from advancements in treatments that target these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by epigenetic alterations, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively target and treat diseases linked to epigenetic changes.
How similar studies have performed: Other research has shown promise in manipulating epigenetic pathways, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Liang, Fu-Sen — Case Western Reserve University
- Study coordinator: Liang, Fu-Sen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.