Creating tools to control cell signaling in specific cell types
Directed Evolution of Cell-Type Specific On-Demand Signaling Control Systems
This study is exploring new ways to use light to control certain brain receptors that affect how we feel pleasure and reward, which could help us understand more about health and diseases related to these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11014635 on NIH RePORTER |
What this research studies
This research focuses on developing innovative tools that allow for precise control of G-protein coupled receptors (GPCRs) in specific cell types using light. GPCRs are crucial for many biological processes, including taste, smell, and hormone regulation. By utilizing directed evolution techniques, the research aims to create photoswitchable modulators that can fine-tune GPCR activity, which could lead to a better understanding of how these receptors influence health and disease. The project will specifically target dopamine receptors to enhance our knowledge of reward signaling in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to dopamine signaling, such as Parkinson's disease or addiction disorders.
Not a fit: Patients with conditions unrelated to GPCR signaling or those who do not have a specific cell-type signaling issue may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that precisely manipulate cell signaling, improving treatment options for various diseases.
How similar studies have performed: Previous research has shown promise in using directed evolution for GPCRs, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: English, Justin G. — University of Utah
- Study coordinator: English, Justin G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.