Creating targeted treatments to improve bone health and prevent fractures
Developing and evaluating bone targeting agents to mimic the skeletal effects of mechanical loading
['FUNDING_R21'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10709497
This study is looking at new treatments that can help strengthen bones and reduce fractures for people with osteoporosis by delivering medicine directly to the bones, making it safer and more effective.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10709497 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new bone-targeting agents that can mimic the beneficial effects of mechanical loading on bone health. By using bisphosphonate conjugation, the researchers aim to deliver treatments directly to the bone, minimizing side effects that typically affect other organs. The study will explore how inhibiting specific pathways in bone cells can enhance bone formation and reduce the risk of fractures, particularly in individuals with osteoporosis. Patients may be involved in clinical trials to evaluate the effectiveness and safety of these new agents.
Who could benefit from this research
Good fit: Ideal candidates for this research include men and women over the age of 50 who are at risk for osteoporosis and related fractures.
Not a fit: Patients who do not have osteoporosis or are not at risk for bone fractures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for osteoporosis, significantly reducing the risk of fractures and improving quality of life for patients.
How similar studies have performed: Previous research has shown promise in using targeted drug delivery systems for bone health, indicating that this approach may be effective.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SATO, TADATOSHI — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: SATO, TADATOSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.