Creating targeted treatments for opioid addiction
Official title: Developing high-precision epigenetic therapeutics for opioid use disorder
Funded at Boston Interactome LLC · NIH-11169512 · Data updated 2026-11-12
This study is exploring new treatments for opioid addiction that aim to work better and have fewer side effects, so people struggling with this issue can find a safer and more effective way to recover.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Interactome LLC NIH-funded |
| Lab location | 1 site (Mansfield, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $398,137 |
| NIH project number | 1R43DA063250-01 |
| Project ID | NIH-11169512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing opioid use disorder.
✕Less likely to help
Patients who are not affected by opioid use disorder or are under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing new epigenetic therapies specifically designed to treat opioid use disorder (OUD). It aims to address the limitations of current treatments, which often have significant side effects and do not effectively target the underlying causes of addiction. By utilizing high-precision small molecules that disrupt specific protein interactions, the research seeks to minimize off-target effects while effectively altering the brain's reward circuitry. Patients may benefit from a more effective and safer treatment option for opioid addiction.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment for individuals struggling with opioid use disorder.
How similar studies have gone: While the approach of targeting epigenetic mechanisms is relatively novel, there is growing interest and preliminary success in similar strategies for treating addiction.
Where this research is happening
-
Boston Interactome LLC
Mansfield, United States Active
Researchers
- Principal investigator: Choi, Soongang — Boston Interactome LLC
- Study coordinator: Choi, Soongang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.