Creating targeted treatments for opioid addiction
Developing high-precision epigenetic therapeutics for opioid use disorder
This study is exploring new treatments for opioid addiction that aim to work better and have fewer side effects, so people struggling with this issue can find a safer and more effective way to recover.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Interactome LLC NIH-funded |
| Lab location | 1 site (Mansfield, United States) |
| Project ID | NIH-11169512 on NIH RePORTER |
What this research studies
This research focuses on developing new epigenetic therapies specifically designed to treat opioid use disorder (OUD). It aims to address the limitations of current treatments, which often have significant side effects and do not effectively target the underlying causes of addiction. By utilizing high-precision small molecules that disrupt specific protein interactions, the research seeks to minimize off-target effects while effectively altering the brain's reward circuitry. Patients may benefit from a more effective and safer treatment option for opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing opioid use disorder.
Not a fit: Patients who are not affected by opioid use disorder or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment for individuals struggling with opioid use disorder.
How similar studies have performed: While the approach of targeting epigenetic mechanisms is relatively novel, there is growing interest and preliminary success in similar strategies for treating addiction.
Where this research is happening
Mansfield, United States
- Boston Interactome LLC — Mansfield, United States (Active)
Researchers
- Principal investigator: Choi, Soongang — Boston Interactome LLC
- Study coordinator: Choi, Soongang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.