Creating targeted inhibitors for specific enzymes involved in inflammation
Official title: Development of Location-specific Sialidase Inhibitors
Funded at Cleveland State University · NIH-10359898 · Data updated 2026-11-12
This study is looking for new ways to block certain enzymes that can worsen inflammation and affect the immune system, with the hope of finding better treatments for serious conditions like sepsis.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $445,500 |
| NIH project number | 1R15GM144881-01 |
| Project ID | NIH-10359898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals suffering from chronic inflammatory disorders, such as sepsis or other related conditions.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by sialidase-related pathways may not benefit from this research.
What this research studies
This research focuses on developing inhibitors for sialidases, enzymes that remove sialic acid from glycoproteins and glycolipids, which play a role in various diseases, including inflammatory disorders. The project aims to understand how these enzymes affect immune responses, particularly through their interaction with the TLR4 receptor on macrophages. By profiling the expression of these enzymes and testing new inhibitors, the research seeks to find effective treatments for conditions like sepsis that currently lack specific pharmacological options.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory diseases, improving patient outcomes and providing targeted therapies.
How similar studies have gone: While the approach of developing specific sialidase inhibitors is relatively novel, previous studies have shown promise in targeting similar pathways for therapeutic benefits.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Sun, Xue-Long — Cleveland State University
- Study coordinator: Sun, Xue-Long
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.