Creating targeted drug delivery systems for treating venous malformations in children
Supplement: Developing Nanoparticle Drug Delivery Systems for Venous Malformations
['FUNDING_CAREER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11111578
This study is exploring new ways to deliver medicine directly to venous malformations in children, using tiny particles that can target the problem areas and reduce side effects, making treatment safer and more effective.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11111578 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative drug delivery systems specifically designed to treat venous malformations (VMs) in children. VMs are slow-flow vascular lesions that can cause pain, disfigurement, and functional impairment. The approach involves using nanoparticles that can deliver medication directly to the affected areas while minimizing side effects associated with traditional systemic treatments. By utilizing techniques such as enhanced permeation and retention (EPR) and photo-targeting, the nanoparticles can be activated to release drugs precisely where needed, improving treatment efficacy and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with venous malformations.
Not a fit: Patients with venous malformations who are older than 11 years or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for children suffering from venous malformations.
How similar studies have performed: Previous research has shown promising results with targeted drug delivery systems in similar contexts, indicating potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CULLION, KATHLEEN — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: CULLION, KATHLEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Disease, Disorder