Creating targeted drug delivery systems for treating venous malformations in children
Developing Nanoparticle Drug Delivery Systems for Venous Malformations
This study is exploring a new way to help children with venous malformations by using tiny particles to deliver medicine right where it's needed, aiming to reduce side effects and improve treatment effectiveness.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10880300 on NIH RePORTER |
What this research studies
This research focuses on developing innovative nanoparticle drug delivery systems specifically designed to treat venous malformations (VMs) in children. VMs are slow-flow vascular lesions that can cause disfigurement, pain, and functional impairment. The approach involves using nanoparticles that can deliver medication directly to the affected areas while minimizing side effects associated with systemic drug delivery. By utilizing a technique called enhanced permeation and retention (EPR), the nanoparticles will preferentially accumulate in the VMs, and active targeting methods will ensure that the treatment is effective and localized.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with venous malformations.
Not a fit: Patients with venous malformations who are older than 11 years or those who do not have this specific condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for children suffering from venous malformations.
How similar studies have performed: Previous research has shown promise in using targeted nanoparticle delivery systems for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cullion, Kathleen — Boston Children's Hospital
- Study coordinator: Cullion, Kathleen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.