Creating T cells to control HIV-1 infection
Engineering T cells to Provide Durable Control of HIV-1 Replication
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10837828
This study is testing a new way to help people with HIV by using specially modified T cells that can fight the virus on their own, so they might not need to take medication all the time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10837828 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new approach to treat HIV-1 by engineering T cells that can resist the virus and control its replication without the need for ongoing antiretroviral therapy. The project involves infusing patients with specially modified T cells that can recognize and attack HIV-infected cells. Researchers are also studying how these engineered T cells behave in the body to enhance their effectiveness and longevity. The ultimate goal is to create a durable immune response that can keep HIV at bay.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are currently undergoing treatment and are interested in innovative therapeutic options.
Not a fit: Patients who are not infected with HIV-1 or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV-1, allowing patients to live without continuous antiretroviral therapy.
How similar studies have performed: Previous research has shown promise in using engineered T cells for other viral infections, indicating potential for success in this novel approach for HIV.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RILEY, JAMES L. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: RILEY, JAMES L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.