Creating systems to study autoimmune processes in type 1 diabetes
Microphysiological systems for modeling autoimmunity in type 1 diabetes
This study is working on creating tiny models that mimic how the immune system attacks insulin-producing cells in type 1 diabetes, with the hope of finding new ways to protect these cells and improve treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10665007 on NIH RePORTER |
What this research studies
This research focuses on developing advanced microphysiological systems that mimic the human immune response and islet cell interactions in type 1 diabetes (T1D). By utilizing tissue-on-a-chip technology, the team aims to create models that replicate the autoimmune attack on insulin-producing islet cells. The research will involve creating new cell lines and assays to better understand how immune cells infiltrate and damage islet cells, as well as exploring potential cellular therapies to halt this process. Patients may benefit from insights gained through these innovative models that could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes, particularly those experiencing autoimmune complications.
Not a fit: Patients with type 2 diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating type 1 diabetes by identifying new therapeutic targets.
How similar studies have performed: Previous research using similar tissue-on-a-chip technologies has shown promise in modeling autoimmune diseases, indicating potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Stanger, Ben Z — University of Pennsylvania
- Study coordinator: Stanger, Ben Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.