Creating synthetic mimics of enzymes and antibodies to target complex biological molecules.
Official title: Mimics of Enzymes and Antibodies for Glycans and Other Biological Targets
Funded at Iowa State University · NIH-11010688 · Data updated 2026-11-12
This study is exploring new tiny particles that can act like natural enzymes and antibodies to better connect with important biological molecules, which could help us understand how our bodies work and lead to new treatments for various health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | April 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $439,992 |
| NIH project number | 1R35GM156461-01 |
| Project ID | NIH-11010688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to glycan and protein dysfunction, such as certain autoimmune diseases or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to glycan or protein interactions may not receive any benefit from this research.
What this research studies
This research focuses on developing synthetic mimics of enzymes and antibodies that can effectively bind to complex biological molecules such as glycans and proteins. The approach involves creating water-soluble nanoparticles that can mimic the action of natural enzymes, allowing for more precise targeting and interaction with these biological targets. By enhancing the binding affinity and specificity of these mimics, the research aims to improve our understanding of biological processes and potentially lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases related to glycan and protein interactions, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using synthetic mimics for biological interactions, indicating a potential for success in this novel approach.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Zhao, Yan — Iowa State University
- Study coordinator: Zhao, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.