Creating synthetic collagen-like peptides to study protein interactions
Peptide Mimics of the Collagen Triple Helix
This study is exploring new synthetic proteins that act like collagen to see how they can help improve cell growth and health, which could lead to better treatments for people with collagen-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11042750 on NIH RePORTER |
What this research studies
This research focuses on developing synthetic peptides that mimic the structure of collagen, a crucial protein in the body. By modifying the amino acids in these peptides, the researchers aim to enhance their stability and ability to interact with other proteins. The project involves synthesizing these peptides using advanced techniques and characterizing their properties to understand how they can influence biological processes such as cell growth and apoptosis. Patients may benefit from insights gained about collagen interactions, which could lead to new treatments for conditions related to collagen dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to collagen abnormalities or those at risk for diseases influenced by collagen interactions.
Not a fit: Patients with conditions unrelated to collagen or those who do not have any known collagen-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases involving collagen, such as certain cancers and connective tissue disorders.
How similar studies have performed: Previous research has shown promise in using peptide mimics to study protein interactions, indicating that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Chenoweth, David Michael — University of Pennsylvania
- Study coordinator: Chenoweth, David Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.