Creating synthetic chromosomes for advanced genetic research
Mendelian inheritance of artificial chromosomes
This study is looking at new ways to create artificial chromosomes in mice to help us understand genetics better, which could lead to better treatments and even personalized organs for people who need transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10888195 on NIH RePORTER |
What this research studies
This research focuses on developing synthetic mammalian artificial chromosomes (MACs) to enhance our understanding of genetic inheritance and improve biotechnology applications. By constructing MACs that can be reliably inherited through generations, the project aims to create humanized animal models for drug testing and potentially develop personalized organs for transplantation. The research utilizes mouse models to explore the complexities of chromosome pairing and recombination during reproduction, addressing significant challenges in synthetic biology. Patients may benefit from advancements in treatments and organ transplantation derived from this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with genetic disorders or those in need of organ transplants.
Not a fit: Patients with conditions unrelated to genetic inheritance or those not requiring organ transplants may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking advancements in personalized medicine and organ transplantation.
How similar studies have performed: Other research in synthetic biology has shown promise, but the specific approach of creating fully functional synthetic chromosomes is relatively novel and untested.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Black, Ben E. — University of Pennsylvania
- Study coordinator: Black, Ben E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.