Creating stem cells to understand and treat lung diseases
Developing Pluripotent Stem Cells to Model and Treat Lung Disease
This study is exploring new ways to treat genetic lung diseases by using special stem cells and gene editing, so that patients can eventually have treatments that tackle the actual causes of their conditions instead of just easing the symptoms.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11046597 on NIH RePORTER |
What this research studies
This research focuses on using advanced stem cell biology and gene editing techniques to develop new treatments for genetic lung diseases. By creating induced pluripotent stem cells (iPSCs) that carry specific genetic mutations, researchers aim to model these diseases and explore potential therapies. The project will utilize human organoid models to better understand lung function and disease mechanisms, ultimately translating these findings into clinical applications. Patients may benefit from innovative treatments that address the root causes of their lung conditions rather than just managing symptoms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic lung diseases affecting the airway and alveoli.
Not a fit: Patients with non-genetic lung diseases or those whose conditions do not involve the airway or alveolar structures may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that effectively treat genetic lung diseases.
How similar studies have performed: Previous research has shown promise in using stem cell and gene editing approaches for treating various genetic conditions, indicating potential success for this novel application in lung diseases.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Kotton, Darrell N. — Boston University Medical Campus
- Study coordinator: Kotton, Darrell N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.