Creating stem cells to compare human and primate genetics
Development of iPSCs for comparative genomics in primates
This study is looking at how human and chimpanzee cells are different to help us understand what makes us human, and it’s for anyone curious about genetics and how it relates to our health and evolution.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11080283 on NIH RePORTER |
What this research studies
This research focuses on developing induced pluripotent stem cells (iPSCs) from humans and chimpanzees to explore the genetic differences that contribute to human-specific traits. By using these stem cells, researchers aim to overcome ethical and practical challenges associated with studying live primates and to better understand gene regulation across species. The project will utilize advanced genomic techniques to analyze gene regulatory differences, which could provide insights into human evolution and health. The findings may help in identifying genetic factors that influence various traits and conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in genetic studies, particularly those with a focus on human evolution and genetic disorders.
Not a fit: Patients with conditions unrelated to genetic regulation or those who do not have an interest in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of human genetics and lead to advancements in medical treatments and therapies.
How similar studies have performed: Previous research using iPSCs for comparative genomics has shown promise, indicating that this approach could yield valuable insights into genetic differences.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Gilad, Yoav — University of Chicago
- Study coordinator: Gilad, Yoav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.