Creating special mice to study pain-sensing nerve cells
Generating NTRK3-FlpO Mice for Genetically Intersecting A-beta Nociceptors
['FUNDING_R21'] · UNIVERSITY OF PENNSYLVANIA · NIH-11116602
This study is creating special mice to help scientists learn more about a type of nerve cell that helps us feel pain, so they can find better ways to understand and treat pain in people.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11116602 on ClinicalTrials.gov |
What this research studies
This research focuses on generating a new line of genetically modified mice that will allow scientists to study a specific type of pain-sensing nerve cells known as Aβ nociceptors. These cells play a crucial role in how we perceive pain, and the research aims to use advanced genetic techniques to manipulate and observe these cells in action. By understanding how these neurons function, researchers hope to uncover new insights into pain mechanisms and potential treatments. The study will involve creating these mice using CRISPR technology and characterizing their genetic properties.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from acute pain or conditions related to pain sensitivity.
Not a fit: Patients with chronic pain conditions that do not involve Aβ nociceptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating acute pain and conditions related to pain perception.
How similar studies have performed: While the approach of using intersectional genetic mapping is established, the specific focus on Aβ nociceptors in this context is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUO, WENQIN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LUO, WENQIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder