Creating soluble forms of amyloid proteins linked to Alzheimer's disease
Official title: Patching Amyloid Surface onto Soluble Protein
Funded at University of California, San Francisco · NIH-10785633 · Data updated 2026-11-12
This study is looking at how certain proteins related to Alzheimer's disease behave, with the hope of creating better ways to test new treatments and drugs that could help people with the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $119,071 |
| NIH project number | 1K99AG084926-01 |
| Project ID | NIH-10785633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-Alzheimer's related cognitive impairments or other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the interactions of tau amyloid proteins, which are crucial in Alzheimer's disease and related dementias. By using advanced techniques, the researchers aim to recreate the specific three-dimensional structures of these proteins that are observed in patients. This approach will help in developing new methods for drug screening and treatment development, as traditional methods struggle with insoluble amyloids. The goal is to generate soluble forms of these proteins to facilitate better understanding and potential therapies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Alzheimer's disease and related dementias by improving drug development processes.
How similar studies have gone: Other research has shown promise in using similar approaches to study amyloid proteins, indicating potential for success in this area.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yang, Hyunjun — University of California, San Francisco
- Study coordinator: Yang, Hyunjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.