Creating sensors to detect natural pain-relieving substances in the brain
Design of genetically encoded sensors for detecting endogenous opioid peptides
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10871822
This study is working on new tools to help scientists see how natural pain-relieving substances in the brain work, which could lead to safer pain medications for people who need them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10871822 on ClinicalTrials.gov |
What this research studies
This research focuses on developing genetically encoded sensors that can accurately detect the release of endogenous opioid peptides in the brain. These natural substances are crucial for pain modulation but are often overshadowed by synthetic opioids that can cause severe side effects. By improving detection methods, the research aims to understand how these peptides function in different neural circuits, potentially leading to the creation of safer pain medications. The approach involves advanced techniques to achieve high-resolution detection of these peptides in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain who may benefit from safer pain management options.
Not a fit: Patients who do not experience chronic pain or those who are not affected by opioid-related side effects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new pain medications that minimize the risk of addiction and other side effects associated with current opioid treatments.
How similar studies have performed: Previous research has shown promise in developing similar detection methods for neuropeptides, indicating potential for success in this novel approach.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, WENJING — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: WANG, WENJING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.