Creating proteins that can switch functions based on binding molecules
Combining protein and DNA engineering to create bioswitches
This study is working on creating special proteins that can change shape when they interact with certain molecules, like DNA or RNA, to help scientists easily see and understand genetic information using just a cell phone camera, which could be really helpful for improving gene editing and studying how cells communicate.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10900596 on NIH RePORTER |
What this research studies
This research focuses on engineering ordinary proteins to act as conformational switches that can be activated by specific ligands, such as DNA or RNA. By utilizing a combination of biophysical, computational, and cellular methods, the project aims to develop three families of protein switches, including biosensors that can detect specific genetic sequences. These biosensors will provide a visual output that can be easily captured using a cell phone camera, making them accessible for various applications in biology and medicine. The goal is to explore the potential of these engineered proteins to revolutionize gene editing and cellular signaling studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers that could benefit from advanced gene editing technologies.
Not a fit: Patients with conditions unrelated to genetic manipulation or those not requiring innovative biosensing technologies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative tools for gene editing and improved understanding of cellular processes, benefiting patients with genetic disorders or cancers.
How similar studies have performed: Other research has successfully developed similar protein-based switches, indicating a promising avenue for further exploration in this area.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Loh, Stewart N — Upstate Medical University
- Study coordinator: Loh, Stewart N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.