Creating personalized vaccines for neuroblastoma in children
Personalized neuroblastoma vaccines
['FUNDING_U01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10890109
This study is working on creating special vaccines just for kids with high-risk neuroblastoma, a tough type of cancer, to help their immune systems fight the cancer better and hopefully keep it from coming back.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10890109 on ClinicalTrials.gov |
What this research studies
This research focuses on developing personalized vaccines for children with high-risk neuroblastoma, a challenging cancer that often does not respond well to standard treatments. The approach involves identifying unique neoantigens from each patient's tumor to create tailored vaccines that stimulate the immune system to target and eliminate cancer cells. By engaging the body's adaptive immune response, the goal is to reduce the chances of cancer relapse and improve overall survival rates. The research will involve rigorous testing to validate the effectiveness of these personalized vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk neuroblastoma who have not responded adequately to standard therapies.
Not a fit: Patients with low-risk neuroblastoma or those who have already exhausted all treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and reduce the side effects of treatment for children with high-risk neuroblastoma.
How similar studies have performed: Previous research has shown promise in using personalized vaccines for other cancers, indicating potential success for this novel approach in neuroblastoma.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARIS, JOHN M — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: MARIS, JOHN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.