Creating personalized models to understand how substances move in spinal fluid.
Development of Patient-Specific Mathematical Models for the Transport of Solute Molecules in the Cerebrospinal Fluid (CSF) Along the Spinal Canal
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10912715
This study is looking at how fluid moves in your spine to help improve treatments for brain and nerve conditions, making it easier for doctors to deliver medications effectively, especially for pain and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10912715 on ClinicalTrials.gov |
What this research studies
This research focuses on developing individualized mathematical models that simulate the transport of solute molecules in cerebrospinal fluid (CSF) along the spinal canal. By understanding how CSF circulates and transports essential substances, the research aims to address issues related to cognitive and neurological diseases. The approach involves analyzing each patient's unique anatomy and physiological conditions to predict the long-term movement of CSF and its solutes. This could enhance the effectiveness of drug delivery methods, particularly for pain management and cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with neurological disorders or those requiring intrathecal drug delivery.
Not a fit: Patients without neurological conditions or those not requiring specialized drug delivery methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug delivery methods for patients with neurological conditions, enhancing treatment efficacy.
How similar studies have performed: While the approach of creating patient-specific models is innovative, similar methodologies in other areas of drug delivery have shown promising results.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANCHEZ, ANTONIO LUIS — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: SANCHEZ, ANTONIO LUIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.