Creating personalized models of rectal cancer for better treatment options
Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient
This study is creating tiny models of rectal cancer from patients' own tumors to help doctors understand how the cancer grows and how it responds to treatments, with the goal of improving care for people with rectal cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10879791 on NIH RePORTER |
What this research studies
This research focuses on developing organoids, or tumoroids, from rectal cancer patients to create individualized models that accurately mimic the patient's tumors. By growing these tumoroids in a 3-dimensional culture, researchers aim to better understand how rectal cancers behave and respond to treatments like chemotherapy and radiation. The study also seeks to establish a large repository of these tumoroids to facilitate further research and improve treatment predictions for patients. This innovative approach addresses the limitations of existing cancer models that do not accurately represent the disease's local invasion and metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with rectal cancer who are undergoing treatment.
Not a fit: Patients with rectal cancer who are not eligible for treatment or those with very early-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for rectal cancer patients.
How similar studies have performed: Preliminary results from similar approaches have shown promise, indicating that patient-derived tumoroids can effectively mirror the characteristics of original tumors and predict treatment responses.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Smith, Jesse Joshua — Sloan-Kettering Inst Can Research
- Study coordinator: Smith, Jesse Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.