Creating personalized models for repairing heart valves in children with a specific heart condition.
Official title: Toward Patient-Specific Computational Modeling of Tricuspid Valve Repair in Hypoplastic Left Heart Syndrome
Funded at Children's Hosp of Philadelphia · NIH-10917154 · Data updated 2026-11-12
This study is working to make heart surgery better for kids with Hypoplastic Left Heart Syndrome by creating special computer models that help doctors understand how their hearts work, so they can plan surgeries that fit each child's unique needs and improve their health in the long run.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $145,840 |
| NIH project number | 5K25HL168235-02 |
| Project ID | NIH-10917154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children diagnosed with Hypoplastic Left Heart Syndrome who may require tricuspid valve intervention.
✕Less likely to help
Patients with heart conditions other than Hypoplastic Left Heart Syndrome may not benefit from this specific research.
What this research studies
This research focuses on improving surgical outcomes for children with Hypoplastic Left Heart Syndrome (HLHS), a serious heart condition that affects normal blood flow. By developing patient-specific computational models, the research aims to better understand the biomechanical properties of the tricuspid valve, which is often affected in these patients. The approach involves using advanced imaging techniques and computational analysis to tailor surgical interventions based on individual anatomical and functional characteristics. This could lead to more effective treatments and improved long-term health for affected children.
Why it matters
Potential benefit: If successful, this research could significantly enhance the surgical management of tricuspid valve issues in children with HLHS, potentially reducing the risk of heart failure and improving survival rates.
How similar studies have gone: Previous research has shown promise in using computational modeling for heart valve analysis, indicating potential success for this novel approach in HLHS.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Wu, Wensi — Children's Hosp of Philadelphia
- Study coordinator: Wu, Wensi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.