Creating Patient Tumor Models for Cancer Research
PDX Core
This project creates special cancer models from patient tumors to help scientists learn more about gastric and lung cancers, especially in minority populations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11168888 on NIH RePORTER |
What this research studies
This project focuses on building a collection of "patient-derived xenograft" (PDX) models, which are human tumor samples grown in special mice. These models come from patients with gastric or lung cancers, particularly those from racial and ethnic minority groups. By creating 120 such models, researchers can study how different cancers grow and respond to treatments in a living system that closely mimics human disease. This work supports larger research efforts aimed at understanding and addressing cancer disparities.
Who could benefit from this research
Good fit: Patients with gastric or lung cancer, particularly those from racial/ethnic minority groups, who are undergoing tumor removal surgery might be candidates for donating tissue samples.
Not a fit: Patients who do not have gastric or lung cancer, or those not undergoing tumor removal, would not directly benefit from participating in this specific tissue donation effort.
Why it matters
Potential benefit: This work could lead to a better understanding of gastric and lung cancers, especially in diverse patient populations, potentially guiding the development of more effective and personalized treatments in the future.
How similar studies have performed: Patient-derived xenograft models are a well-established tool in cancer research, and similar approaches have successfully advanced our understanding of cancer biology and drug responses.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lloyd, Kc Kent — University of California at Davis
- Study coordinator: Lloyd, Kc Kent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.