Creating paper-based cultures to study tissue-like structures and oxygen effects
Paper-based cultures supporting tissue-like structures for biochemical studies of oxygen gradients and screening applications
This study is exploring a new way to grow tissue-like structures on paper to see how changes in oxygen levels affect cells, especially in breast tissue, which could help us learn more about cancer and improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10765243 on NIH RePORTER |
What this research studies
This research focuses on developing a new culture platform that mimics tissue-like structures to better understand how cells respond to changes in oxygen levels. By using a paper-based system, researchers can create these structures easily and study how oxygen influences cellular functions, particularly in breast tissue models. The approach allows for the examination of complex interactions within tissues, which is crucial for understanding diseases and drug responses. Patients may benefit from insights gained about how oxygen levels affect cancer progression and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ER+ breast cancer who are interested in new treatment approaches.
Not a fit: Patients with non-breast cancers or those not expressing estrogen receptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer biology and more effective treatments for patients with breast cancer.
How similar studies have performed: Other research has shown promise in using engineered tissue models to study cellular responses, indicating that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Lockett, Matthew Ryen — Univ of North Carolina Chapel Hill
- Study coordinator: Lockett, Matthew Ryen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.