Creating organoid models to study rare neuroendocrine cancers
Addressing biological and therapeutic gaps in rare neuroendocrine cancer with a novel organoid-based model
This study is creating tiny lab-grown versions of rare tumors called pheochromocytomas and paragangliomas to help us learn more about how they work and find better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10977416 on NIH RePORTER |
What this research studies
This research focuses on developing organoid models of pheochromocytomas and paragangliomas, which are rare tumors that secrete catecholamines and can originate from adrenal glands or extra adrenal paraganglia. By generating these organoid models, the research aims to better understand the biological mechanisms behind tumor behavior and identify potential therapeutic opportunities. The study will investigate whether these organoids accurately reflect the characteristics of the original tumors and will use them to explore important biological questions that could lead to improved treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pheochromocytomas or paragangliomas, particularly those with aggressive or recurrent forms of these tumors.
Not a fit: Patients with common types of cancer or those without a diagnosis of pheochromocytomas or paragangliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction of clinical outcomes and the discovery of new treatment options for patients with rare neuroendocrine cancers.
How similar studies have performed: While the approach of using organoid models is gaining traction, this specific application to rare neuroendocrine cancers is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Dahia, Patricia Leal — University of Texas Hlth Science Center
- Study coordinator: Dahia, Patricia Leal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.