Creating online resources for understanding protein-DNA and protein-RNA interactions
Official title: CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11124024 · Data updated 2026-11-12
This study is creating easy-to-use online tools that show how proteins work with DNA and RNA, helping scientists understand the genetic factors that affect our health and diseases, and all the information will be available for free to support more research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 24, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $544,784 |
| NIH project number | 5U24HG013078-02 |
| Project ID | NIH-11124024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic disorders or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with conditions unrelated to genetic factors or those not involved in research may not receive direct benefits from this research.
What this research studies
This research focuses on developing and enhancing web-based databases that provide detailed information about how proteins interact with DNA and RNA. By mapping the specificities of transcription factors and RNA-binding proteins, the project aims to organize complex genetic data into user-friendly formats. This will help researchers better understand the genetic and environmental factors that contribute to human health and disease. The data generated will be made freely available to the scientific community, facilitating further research and discovery.
Why it matters
Potential benefit: If successful, this research could significantly advance our understanding of genetic regulation and its impact on human health, potentially leading to improved treatments for various diseases.
How similar studies have gone: Other research efforts in mapping protein-DNA and protein-RNA interactions have shown success, indicating that this approach is both valuable and tested.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Weirauch, Matthew Tyson — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Weirauch, Matthew Tyson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.