Creating new vaccines to help the immune system fight HIV
Official title: Development of soluble and membrane bound immunogens to shepherd HIV-1 MPER specific BCR maturation
Funded at Scripps Research Institute, the · NIH-10924714 · Data updated 2026-11-12
This study is working on new vaccines to help your immune system create powerful antibodies that can fight off different types of HIV, and it's looking for the best ways to deliver these vaccines to boost your protection against the virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 2, 2024 |
| Project end | August 1, 2027 |
| Funding year | 2024 |
| Award (this year) | $35,974 |
| NIH project number | 1F31AI179426-01A1 |
| Project ID | NIH-10924714 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk of HIV infection who are seeking preventive measures.
✕Less likely to help
Patients who are already HIV-positive or those with compromised immune systems may not benefit from this research.
What this research studies
This research focuses on developing innovative vaccines that can stimulate the immune system to produce broadly neutralizing antibodies (bnAbs) against HIV-1. By using engineered immunogens that target specific B cell precursors, the project aims to enhance the body's ability to generate effective antibodies that can neutralize various strains of the virus. The approach involves testing different methods of delivering these immunogens, such as mRNA and protein, to determine the best way to activate and mature the immune response. This research is crucial for advancing HIV prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that significantly reduces the risk of HIV infection.
How similar studies have gone: Previous research has shown promise in using similar approaches to induce bnAbs in animal models, indicating potential for success in this area.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Swanson, Olivia — Scripps Research Institute, the
- Study coordinator: Swanson, Olivia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.