Creating new vaccines to help the immune system fight HIV
Development of soluble and membrane bound immunogens to shepherd HIV-1 MPER specific BCR maturation
['FUNDING_FELLOWSHIP'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10924714
This study is working on new vaccines to help your immune system create powerful antibodies that can fight off different types of HIV, and it's looking for the best ways to deliver these vaccines to boost your protection against the virus.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10924714 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative vaccines that can stimulate the immune system to produce broadly neutralizing antibodies (bnAbs) against HIV-1. By using engineered immunogens that target specific B cell precursors, the project aims to enhance the body's ability to generate effective antibodies that can neutralize various strains of the virus. The approach involves testing different methods of delivering these immunogens, such as mRNA and protein, to determine the best way to activate and mature the immune response. This research is crucial for advancing HIV prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of HIV infection who are seeking preventive measures.
Not a fit: Patients who are already HIV-positive or those with compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that significantly reduces the risk of HIV infection.
How similar studies have performed: Previous research has shown promise in using similar approaches to induce bnAbs in animal models, indicating potential for success in this area.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANSON, OLIVIA — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: SWANSON, OLIVIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus