Creating new types of blood vessel grafts for heart surgery
Cell-free vascular grafts: immunological response and vascular regeneration
This study is exploring new types of blood vessel grafts that can help patients with heart problems, especially those with coronary artery disease, by creating grafts that act like natural blood vessels and help the body heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10594428 on NIH RePORTER |
What this research studies
This research investigates innovative blood vessel grafts that can be used in heart surgeries, particularly for patients with coronary artery disease. The approach focuses on developing acellular tissue-engineered vascular grafts that are designed to mimic natural blood vessels and promote healing. By using specific growth factors, the grafts aim to enhance the body's immune response and improve the integration of the grafts into the patient's vascular system. The research includes testing these grafts in both animal models and human clinical trials to assess their effectiveness and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults suffering from coronary artery disease who may require bypass grafting procedures.
Not a fit: Patients with non-cardiovascular conditions or those who are not candidates for vascular grafting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and readily available blood vessel grafts for patients undergoing heart surgery, potentially improving recovery and outcomes.
How similar studies have performed: Previous research has shown promise in using tissue-engineered vascular grafts, indicating potential for success in this novel approach.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Andreadis, Stelios Theoharis — State University of New York at Buffalo
- Study coordinator: Andreadis, Stelios Theoharis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.